MolNFT v1 · #146288 · protein
Crystal structure of the human vaccinia-related kinase bound to a N,N- dipropyl-dihydropteridine inhibitor
6DD4: “Crystal structure of the human vaccinia-related kinase bound to a N,N- dipropyl-dihydropteridine inhibitor”. X-ray diffraction, 3 ligands (G6J, CL, SO4). MolNFT v1 #146288 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6DD4
- Type
- protein
- Length
- 1,254 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q99986
- Ligands
- G6J, CL, SO4
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 317 | — | Q99986 |
| B | — | protein | 309 | — | Q99986 |
| C | — | protein | 317 | — | Q99986 |
| D | — | protein | 311 | — | Q99986 |
Ligands and binding sites
- G6J · (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5H)-one · ligand · 2 copies · chains B, D
- CL · Chloride ion · ion · 8 copies · chains A, D
- SO4 · Sulfate ion · ion · 6 copies · chains B, C, D
- ACT · Acetate ion · additive · 7 copies · chains A, B, C, D
- GOL · Glycerol · additive · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6DD4 · Crystal Structure of the Human vaccinia-related kinase bound to a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99986
- Elsewhere: RCSB PDB 6DD4 · PDBe 6DD4 · UniProt Q99986
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