MolNFT v1 · #146260 · protein
FAB/EPITOPE complex of mouse monoclonal antibody 8B2 targeting a non- phosphorylated tau epitope.
6DC8 · IgG light chain: “FAB/EPITOPE complex of mouse monoclonal antibody 8B2 targeting a non- phosphorylated tau epitope.”. X-ray diffraction, 2 ligands (NH2, PO4), 5 pockets (best druggability 0.51). MolNFT v1 #146260 on GenesisL1: 3D…
- PDB
- 6DC8
- Type
- protein
- Length
- 440 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IgG light chain; IgG heavy chain; Microtubule-associated protein tau
- UniProt
- P10636
- Ligands
- NH2, PO4
- Pockets
- 5 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IgG light chain | protein | 218 | 6% helix, 53% strand | — |
| H | IgG heavy chain | protein | 217 | 8% helix, 51% strand | — |
| P | Microtubule-associated protein tau | protein | 5 | 0% helix, 0% strand | P10636 |
Ligands and binding sites
- NH2 · Amino group · ion · chains H, P
- PO4 · Phosphate ion · ion · chains L, H, P
- GOL · Glycerol · additive · 3 copies · chains L, H, P
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.51 | 0.74 | 38 | empty |
| 2 | 198 | 0.50 | 0.76 | 38 | empty |
| 3 | 157 | 0.41 | 0.74 | 27 | empty |
| 4 | 94 | 0.36 | 0.74 | 23 | GOL |
| 5 | 64 | 0.31 | 0.75 | 16 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1764 Ų buried · 11 hydrogen bonds · protein-protein
- H–P · 341 Ų buried · 4 hydrogen bonds · protein-protein
- L–P · 280 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6DC8 · Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 6DC8 · PDBe 6DC8 · UniProt P10636
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