MolNFT v1 · #146078 · protein

Solution structure of trigger factor dimer

6D6S: “Solution structure of trigger factor dimer”. Solution nmr, 12 pockets (best druggability 0.80). MolNFT v1 #146078 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6D6S
Type: protein
Length: 864 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trigger factor
EC: 5.2.1.8
UniProt: P0A850
Pockets: 12 · best druggability 0.80

Structure

solution nmr · 1 distinct chain · 47% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Trigger factor (EC 5.2.1.8)	protein	432	47% helix, 19% strand	P0A850

Pockets

12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	222	0.80	0.93	35	empty
2	392	0.80	0.88	46	empty
3	522	0.61	0.74	47	empty
4	356	0.60	0.77	33	empty
5	334	0.53	0.74	35	empty

Interfaces

1 interface between chains.

A–B · 3384 Å² buried · 57 hydrogen bonds · protein-protein

Compared structures

6D6S · Solution structure of Trigger Factor dimer · the same entry in another collection · chain A against A, TM-score 1.00
P0A850 · AlphaFold monomer V2.0 prediction for trigger factor (P0A850) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A850
Elsewhere: RCSB PDB 6D6S · PDBe 6D6S · UniProt P0A850

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