MolNFT v1 · #145999 · protein

Crystal structure of ptp epsilon D2 domain (A455N/V457Y/E597D)

6D4F · Receptor-type tyrosine-protein phosphatase epsilon: “Crystal structure of ptp epsilon D2 domain (A455N/V457Y/E597D)”. X-ray diffraction, 3 pockets (best druggability 0.50). MolNFT v1 #145999 on GenesisL1: 3D structure, binding sites…

PDB: 6D4F
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase epsilon
EC: 3.1.3.48
UniProt: P23469
Pockets: 3 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase epsilon (EC 3.1.3.48)	protein	269	35% helix, 22% strand	P23469

Ligands and binding sites

1PE · Pentaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.50	0.78	24	empty
2	112	0.49	0.80	21	empty
3	69	0.33	0.76	12	empty

Compared structures

6D4F · Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D) · the same entry in another collection · chain A against A, TM-score 1.00
P23469 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase epsilon… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23469
Elsewhere: RCSB PDB 6D4F · PDBe 6D4F · UniProt P23469

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.