MolNFT v1 · #145964 · protein
Crystal structure of the ptp epsilon D2 domain
6D3F · Receptor-type tyrosine-protein phosphatase epsilon: “Crystal structure of the ptp epsilon D2 domain”. X-ray diffraction, 6 pockets (best druggability 0.71). MolNFT v1 #145964 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6D3F
- Type
- protein
- Length
- 543 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase epsilon
- EC
- 3.1.3.48
- UniProt
- P23469
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase epsilon (EC 3.1.3.48) | protein | 275 | 37% helix, 22% strand | P23469 |
| B | Receptor-type tyrosine-protein phosphatase epsilon (EC 3.1.3.48) | protein | 268 | 37% helix, 20% strand | P23469 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 860 | 0.71 | 0.76 | 79 | empty |
| 2 | 64 | 0.46 | 0.83 | 15 | empty |
| 3 | 120 | 0.40 | 0.75 | 25 | empty |
| 4 | 74 | 0.37 | 0.78 | 18 | empty |
| 5 | 84 | 0.36 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 420 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6D3F · Crystal Structure of the PTP epsilon D2 domain · the same entry in another collection · chain A against A, TM-score 1.00
- P23469 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase epsilon… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23469
- Elsewhere: RCSB PDB 6D3F · PDBe 6D3F · UniProt P23469
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.