MolNFT v1 · #145886 · protein
Zebrafish TRAP1 bound to amppnp and calcium in the asymmetric closed state
6D14 · TNF receptor-associated protein 1: “Zebrafish TRAP1 bound to amppnp and calcium in the asymmetric closed state”. X-ray diffraction, 2 ligands (ANP, CA), 17 pockets (best druggability 0.79). MolNFT v1 #145886 on GenesisL1: 3D…
- PDB
- 6D14
- Type
- protein
- Length
- 1,185 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor-associated protein 1
- UniProt
- A8WFV1
- Ligands
- ANP, CA
- Pockets
- 17 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor-associated protein 1 | protein | 580 | 38% helix, 20% strand | A8WFV1 |
| B | TNF receptor-associated protein 1 | protein | 605 | 41% helix, 21% strand | A8WFV1 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.79 | 0.91 | 50 | ANP, CA |
| 2 | 277 | 0.75 | 0.88 | 44 | ANP |
| 3 | 623 | 0.69 | 0.78 | 70 | empty |
| 4 | 430 | 0.67 | 0.79 | 48 | empty |
| 5 | 510 | 0.63 | 0.76 | 46 | empty |
Interfaces
1 interface between chains.
- A–B · 5752 Ų buried · 71 hydrogen bonds · protein-protein
Compared structures
- 6D14 · Zebrafish TRAP1 bound to AMPPNP and calcium in the asymmetric closed state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8WFV1
- Elsewhere: RCSB PDB 6D14 · PDBe 6D14 · UniProt A8WFV1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.