MolNFT v1 · #145759 · protein
Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 1
6CXI · Actin, cytoplasmic 2: “Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 1”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #145759 on GenesisL1: 3D structure, binding…
- PDB
- 6CXI
- Type
- protein
- Length
- 3,429 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, cytoplasmic 2; Myosin-binding protein C, cardiac-type; Tropomyosin
- UniProt
- P63261, Q14896
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 50% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Actin, cytoplasmic 2 | protein | 370 | 44% helix, 19% strand | P63261 |
| G, H, I, J, K, L | Myosin-binding protein C, cardiac-type | protein | 104 | 7% helix, 56% strand | Q14896 |
| M, N, O, P, Q | Myosin-binding protein C, cardiac-type | protein | 95 | 3% helix, 47% strand | Q14896 |
| S, T | Tropomyosin | protein | 127 | 98% helix, 0% strand | — |
| U, V | Tropomyosin | protein | 113 | 98% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.82 | 0.94 | 45 | empty |
| 2 | 192 | 0.81 | 0.95 | 45 | empty |
| 3 | 1162 | 0.79 | 0.81 | 107 | empty |
| 4 | 202 | 0.79 | 0.93 | 40 | empty |
| 5 | 292 | 0.78 | 0.90 | 55 | empty |
Interfaces
38 interfaces between chains.
- S–T · 1713 Ų buried · 0 hydrogen bonds · protein-protein
- U–V · 1430 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 1218 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 1176 Ų buried · 9 hydrogen bonds · protein-protein
- C–E · 1139 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6CXI · Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C… · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63261
- Every structure of UniProt Q14896
- Elsewhere: RCSB PDB 6CXI · PDBe 6CXI · UniProt P63261 · UniProt Q14896
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