MolNFT v1 · #145738 · protein
Crystal structure of human ribonuclease P/MRP proteins RPP20/RPP25
6CWX · Ribonuclease P protein subunit P20: “Crystal structure of human ribonuclease P/MRP proteins RPP20/RPP25”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.34). MolNFT v1 #145738 on GenesisL1: 3D structure, binding…
- PDB
- 6CWX
- Type
- protein
- Length
- 226 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease P protein subunit P20; Ribonuclease P protein subunit P25
- EC
- 3.1.26.5
- UniProt
- O75817, Q9BUL9
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonuclease P protein subunit P20 (EC 3.1.26.5) | protein | 105 | 28% helix, 41% strand | O75817 |
| B | Ribonuclease P protein subunit P25 (EC 3.1.26.5) | protein | 121 | 25% helix, 34% strand | Q9BUL9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.34 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 775 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (artifact).
Compared structures
- 6CWX · Crystal structure of human ribonuclease P/MRP proteins Rpp20/Rpp25 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BUL9 · AlphaFold monomer V2.0 prediction for ribonuclease P protein subunit P25 (Q9BUL9) · a predicted model of the same protein · chain B against A, TM-score 0.92
- O75817 · AlphaFold monomer V2.0 prediction for ribonuclease P protein subunit P20 (O75817) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75817
- Every structure of UniProt Q9BUL9
- Elsewhere: RCSB PDB 6CWX · PDBe 6CWX · UniProt O75817 · UniProt Q9BUL9
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