MolNFT v1 · #145680 · protein

Cytoplasmic domain of MTRPC6

6CV9 · Short transient receptor potential channel 6: “Cytoplasmic domain of MTRPC6”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #145680 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6CV9
Type: protein
Length: 1,264 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Short transient receptor potential channel 6
UniProt: Q61143
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 61% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Short transient receptor potential channel 6	protein	316	61% helix, 0% strand	Q61143

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	878	0.84	0.86	73	empty
2	897	0.84	0.86	82	empty
3	837	0.83	0.86	78	empty
4	1120	0.83	0.84	91	empty
5	168	0.80	0.95	19	empty

Interfaces

6 interfaces between chains.

A–B · 1801 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 1720 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 1707 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 1706 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 40 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6CV9 · Cytoplasmic domain of mTRPC6 · the same entry in another collection · chain A against A, TM-score 1.00
Q61143 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 6… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q61143
Elsewhere: RCSB PDB 6CV9 · PDBe 6CV9 · UniProt Q61143

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.