MolNFT v1 · #145593 · protein
Crystal structure of the designed light-gated anion channel ic++ at PH6.5
6CSO: “Crystal structure of the designed light-gated anion channel ic++ at PH6.5”. X-ray diffraction, 2 ligands (RET, OLA), 4 pockets (best druggability 0.76). MolNFT v1 #145593 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6CSO
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ic++
- Ligands
- RET, OLA
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ic++ | protein | 282 | 65% helix, 8% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.76 | 0.93 | 29 | RET |
| 2 | 147 | 0.50 | 0.79 | 22 | empty |
| 3 | 71 | 0.49 | 0.84 | 15 | empty |
| 4 | 63 | 0.34 | 0.77 | 16 | empty |
Modifications
Observed in the structure: 1 cofactor (retinal Schiff base).
Compared structures
- 6CSO · Crystal structure of the designed light-gated anion channel iC++ at pH6.5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6CSO · PDBe 6CSO
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