MolNFT v1 · #145561 · protein
Cryoem structure of human enterovirus D68 abortive product 1 (pH 7.2 and 4 degrees celsius)
6CRP · Viral protein 1: “Cryoem structure of human enterovirus D68 abortive product 1 (pH 7.2 and 4 degrees celsius)”. Electron microscopy, 11 pockets (best druggability 0.61). MolNFT v1 #145561 on GenesisL1: 3D structure, binding sites…
- PDB
- 6CRP
- Type
- protein
- Length
- 737 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Viral protein 1; Viral protein 3; Viral protein 2; Viral protein 4
- UniProt
- A0A097BW12, A0A1I9KXX3, A0A191Z5D5
- Pockets
- 11 · best druggability 0.61
Structure
electron microscopy · 4 distinct chains · 9% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Viral protein 1 | protein | 242 | 6% helix, 35% strand | A0A097BW12 |
| B | Viral protein 3 | protein | 247 | 8% helix, 29% strand | A0A097BW12 |
| C | Viral protein 2 | protein | 230 | 13% helix, 35% strand | A0A1I9KXX3 |
| D | Viral protein 4 | protein | 18 | 17% helix, 0% strand | A0A191Z5D5 |
Pockets
11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.61 | 0.83 | 26 | empty |
| 2 | 171 | 0.48 | 0.76 | 30 | empty |
| 3 | 86 | 0.36 | 0.75 | 23 | empty |
| 4 | 77 | 0.34 | 0.75 | 19 | empty |
| 5 | 90 | 0.33 | 0.73 | 18 | empty |
Interfaces
5 interfaces between chains.
- A–B · 3869 Ų buried · 67 hydrogen bonds · protein-protein
- A–C · 1868 Ų buried · 44 hydrogen bonds · protein-protein
- B–C · 1860 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 498 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 426 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6CRP · CryoEM structure of human enterovirus D68 abortive product 1 (pH 7.2 and 4 degrees… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A097BW12
- Every structure of UniProt A0A1I9KXX3
- Every structure of UniProt A0A191Z5D5
- Elsewhere: RCSB PDB 6CRP · PDBe 6CRP · UniProt A0A097BW12 · UniProt A0A1I9KXX3 · UniProt A0A191Z5D5
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