Research workbench

Cryoem structure of human enterovirus D68 abortive product 1 (pH 7.2 and 4 degrees celsius)

Analyse Cryoem structure of human enterovirus D68 abortive product 1 (pH 7.2 and 4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6CRP
Type: protein
Length: 737 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Viral protein 1; Viral protein 3; Viral protein 2; Viral protein 4
UniProt: A0A097BW12, A0A1I9KXX3, A0A191Z5D5
Pockets: 11 · best druggability 0.61

Structure

electron microscopy · 4 distinct chains · 9% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Viral protein 1	protein	242	6% helix, 35% strand	A0A097BW12
B	Viral protein 3	protein	247	8% helix, 29% strand	A0A097BW12
C	Viral protein 2	protein	230	13% helix, 35% strand	A0A1I9KXX3
D	Viral protein 4	protein	18	17% helix, 0% strand	A0A191Z5D5

Pockets

11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.61	0.83	26	empty
2	171	0.48	0.76	30	empty
3	86	0.36	0.75	23	empty
4	77	0.34	0.75	19	empty
5	90	0.33	0.73	18	empty

Interfaces

5 interfaces between chains.

A–B · 3869 Å² buried · 67 hydrogen bonds · protein-protein
A–C · 1868 Å² buried · 44 hydrogen bonds · protein-protein
B–C · 1860 Å² buried · 19 hydrogen bonds · protein-protein
B–D · 498 Å² buried · 11 hydrogen bonds · protein-protein
A–D · 426 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6CRP · CryoEM structure of human enterovirus D68 abortive product 1 (pH 7.2 and 4 degrees… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A097BW12
Every structure of UniProt A0A1I9KXX3
Every structure of UniProt A0A191Z5D5
Elsewhere: RCSB PDB 6CRP · PDBe 6CRP · UniProt A0A097BW12 · UniProt A0A1I9KXX3 · UniProt A0A191Z5D5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.