MolNFT v1 · #14551 · protein

Structure of full-length annexin A1 in the presence of calcium

1MCX · Annexin I: “Structure of full-length annexin A1 in the presence of calcium”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.50). MolNFT v1 #14551 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MCX
Type: protein
Length: 304 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin I
UniProt: P19619
Ligands: CA
Pockets: 3 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin I	protein	304	74% helix, 0% strand	P19619

Ligands and binding sites

CA · Calcium ion · metal · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.50	0.83	21	empty
2	117	0.39	0.74	21	empty
3	59	0.30	0.75	15	empty

Compared structures

1MCX · Structure of full-length annexin A1 in the presence of calcium · the same entry in another collection · chain A against A, TM-score 1.00
P19619 · AlphaFold monomer V2.0 prediction for annexin A1 (P19619) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19619
Elsewhere: RCSB PDB 1MCX · PDBe 1MCX · UniProt P19619

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