MolNFT v1 · #145466 · protein
Human clc-1 chloride ion channel, transmembrane domain
6COY · Chloride channel protein 1: “Human clc-1 chloride ion channel, transmembrane domain”. Electron microscopy, 1 ligand (CL), 13 pockets (best druggability 0.78). MolNFT v1 #145466 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6COY
- Type
- protein
- Length
- 930 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride channel protein 1
- UniProt
- P35523
- Ligands
- CL
- Pockets
- 13 · best druggability 0.78
Structure
electron microscopy · 1 distinct chain · 70% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chloride channel protein 1 | protein | 465 | 70% helix, 3% strand | P35523 |
Ligands and binding sites
- CL · Chloride ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 600 | 0.78 | 0.84 | 73 | empty |
| 2 | 593 | 0.78 | 0.84 | 74 | empty |
| 3 | 379 | 0.65 | 0.79 | 41 | CL |
| 4 | 359 | 0.64 | 0.79 | 41 | CL |
| 5 | 135 | 0.59 | 0.84 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 2369 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35523
- Elsewhere: RCSB PDB 6COY · PDBe 6COY · UniProt P35523
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