MolNFT v1 · #145434 · protein
Structure of human tirr in complex with 53BP1 tudor domains
6CO1 · Tudor-interacting repair regulator protein: “Structure of human tirr in complex with 53BP1 tudor domains”. X-ray diffraction, 14 pockets (best druggability 0.80). MolNFT v1 #145434 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6CO1
- Type
- protein
- Length
- 1,043 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tudor-interacting repair regulator protein; TP53-binding protein 1
- UniProt
- Q9BRJ7, Q12888
- Pockets
- 14 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 28% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Tudor-interacting repair regulator protein | protein | 201 | 35% helix, 32% strand | Q9BRJ7 |
| B | Tudor-interacting repair regulator protein | protein | 200 | 36% helix, 32% strand | Q9BRJ7 |
| C | Tudor-interacting repair regulator protein | protein | 202 | 35% helix, 31% strand | Q9BRJ7 |
| E | TP53-binding protein 1 | protein | 120 | 10% helix, 54% strand | Q12888 |
| F | TP53-binding protein 1 | protein | 119 | 13% helix, 55% strand | Q12888 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 780 | 0.80 | 0.84 | 102 | empty |
| 2 | 468 | 0.73 | 0.82 | 62 | empty |
| 3 | 63 | 0.73 | 0.98 | 19 | empty |
| 4 | 327 | 0.69 | 0.83 | 38 | empty |
| 5 | 207 | 0.57 | 0.80 | 33 | empty |
Interfaces
13 interfaces between chains.
- C–D · 1716 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1646 Ų buried · 18 hydrogen bonds · protein-protein
- A–E · 635 Ų buried · 10 hydrogen bonds · protein-protein
- D–F · 631 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 254 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6CO1 · Structure of human TIRR in complex with 53BP1 Tudor domains · the same entry in another collection · chain F against F, TM-score 1.00
- Q9BRJ7 · AlphaFold monomer V2.0 prediction for tudor-interacting repair regulator protein (Q9BRJ7) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q12888 · AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) · a predicted model of the same protein · chain E against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BRJ7
- Every structure of UniProt Q12888
- Elsewhere: RCSB PDB 6CO1 · PDBe 6CO1 · UniProt Q9BRJ7 · UniProt Q12888
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