MolNFT v1 · #145417 · protein
Human PRPF4B in complex with rebastinib
6CNH · SERINE/THREONINE-protein kinase PRP4 homolog: “Human PRPF4B in complex with rebastinib”. X-ray diffraction, 2 ligands (919, SO4), 2 pockets (best druggability 0.74). MolNFT v1 #145417 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6CNH
- Type
- protein
- Length
- 321 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PRP4 homolog
- EC
- 2.7.11.1
- UniProt
- Q13523
- Ligands
- 919, SO4
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PRP4 homolog (EC 2.7.11.1) | protein | 321 | 41% helix, 18% strand | Q13523 |
Ligands and binding sites
- 919 · 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide · ligand · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.74 | 0.85 | 44 | 919, SO4 |
| 2 | 57 | 0.40 | 0.81 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13523
- Elsewhere: RCSB PDB 6CNH · PDBe 6CNH · UniProt Q13523
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