UniProt Q13523
Serine/threonine-protein kinase PRP4 homolog (Q13523)
Serine/threonine-protein kinase PRP4 homolog (UniProt Q13523), EC 2.7.11.1: 17 experimental structures on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q13523
- Protein
- Serine/threonine-protein kinase PRP4 homolog
- EC
- 2.7.11.1
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 4 · 3 records with a druggable one
Structures
17 records of Q13523 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IAN | Crystal Structure of apo Human PRPF4B kinase domain | x-ray diffraction | A, B | — | — |
| 4IAN | Crystal structure of apo human PRPF4B kinase domain | x-ray diffraction | A, B | — | — |
| 4IFC | Crystal Structure of ADP-bound Human PRPF4B kinase domain | x-ray diffraction | A, B | — | — |
| 4IFC | Crystal structure of ADP-bound human PRPF4B kinase domain | x-ray diffraction | A, B | — | — |
| 4IIR | Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain | x-ray diffraction | A, B | — | — |
| 4IIR | Crystal structure of amppnp-bound human PRPF4B kinase domain | x-ray diffraction | A, B | — | — |
| 4IJP | Crystal Structure of Human PRPF4B kinase domain in complex with… | x-ray diffraction | A, B | — | — |
| 4IJP | Crystal structure of human PRPF4B kinase domain in complex with 4-{5… | x-ray diffraction | A, B | — | — |
| 6CNH | Human PRPF4B in complex with Rebastinib | x-ray diffraction | A | 919, SO4 | 2 (best 0.74) |
| 6CNH | Human PRPF4B in complex with rebastinib | x-ray diffraction | A | 919, SO4 | — |
| 6PJJ | Human PRPF4B bound to benzothiophene inhibitor 224 | x-ray diffraction | A, B, C, D | OCJ, PO4 | — |
| 6PK6 | Human PRPF4B bound to benzothiophene inhibitor 329 | x-ray diffraction | A | SO4, OND | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | K | — | 1 (best 0.84) |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 4Y | — | 1 (best 0.83) |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | K | — | — |
| 8Y6O | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP… | electron microscopy | Q | — | — |
| Q13523 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PRP4 homolog (Q13523) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 3 records
- 919 · 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide · in 2 records
- OCJ · 4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide · in 1 record
- OND · 4-(5-{[(2-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide · in 1 record
- PO4 · Phosphate ion · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.