MolNFT v1 · #145306 · protein

Insulin analog containing a YB26W mutation

6CK2 · Insulin a chain: “Insulin analog containing a YB26W mutation”. X-ray diffraction, 3 ligands (IPH, ZN, CL). MolNFT v1 #145306 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6CK2
Type: protein
Length: 98 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin a chain; Insulin B chain
UniProt: P01308
Ligands: IPH, ZN, CL

Structure

x-ray diffraction · 3 distinct chains · 60% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin a chain	protein	21	57% helix, 5% strand	P01308
B	Insulin B chain	protein	29	52% helix, 10% strand	P01308
D	Insulin B chain	protein	27	70% helix, 11% strand	P01308

Ligands and binding sites

IPH · Phenol · ligand · chains C, D
ZN · Zinc ion · metal · 2 copies · chains B, D
CL · Chloride ion · ion · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

A–B · 773 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 645 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 539 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 65 Å² buried · 1 hydrogen bond · protein-protein
B–C · 24 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 1 modified (disulfide, nonstandard).

Compared structures

6CK2 · Insulin analog containing a YB26W mutation · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 6CK2 · PDBe 6CK2 · UniProt P01308

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