Structure of human endothelial nitric oxide synthase heme domain in complex with N-(1-(2-(ETHYL(METHYL)AMINO)ETHYL)-1,2,3,4- tetrahydroquino-lin-6-YL)THIOPHENE-2-carboximidamide

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, B, C, D
• H4B · 5,6,7,8-tetrahydrobiopterin · ligand · 4 copies · chains A, B, C, D
• 7R2 · N-(1-{2-[ethyl(methyl)amino]ethyl}-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide · ligand · 4 copies · chains A, B, C, D
• GD · Gadolinium atom · metal · 4 copies · chains A, B, D
• ZN · Zinc ion · metal · 2 copies · chains A, B, C, D
• CL · Chloride ion · ion · 4 copies · chains A, B, C, D
• BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · 11 copies · chains A, B, C, D
• GOL · Glycerol · additive · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6CIE · Structure of human endothelial nitric oxide synthase heme domain in complex with… · the same entry in another collection · chain C against C, TM-score 1.00

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• Elsewhere: RCSB PDB 6CIE · PDBe 6CIE · UniProt P29474