MolNFT v1 · #145190 · protein

Mouse cadherin-7 EC1-2 adhesive fragment

6CGS: “Mouse cadherin-7 EC1-2 adhesive fragment”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.63). MolNFT v1 #145190 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6CGS
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cadherin-7
UniProt: Q8BM92
Ligands: CA
Pockets: 2 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 1% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cadherin-7	protein	207	1% helix, 44% strand	Q8BM92

Ligands and binding sites

CA · Calcium ion · metal · 6 copies · chains A, B
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	403	0.63	0.77	48	empty
2	142	0.54	0.81	27	empty

Interfaces

1 interface between chains.

A–B · 1156 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

6CGS · mouse cadherin-7 EC1-2 adhesive fragment · the same entry in another collection · chain A against A, TM-score 1.00
Q8BM92 · AlphaFold monomer V2.0 prediction for cadherin-7 (Q8BM92) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BM92
Elsewhere: RCSB PDB 6CGS · PDBe 6CGS · UniProt Q8BM92

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