MolNFT v1 · #145078 · protein

Human CTBP1 (28-378)

6CDF · C-terminal-binding protein 1: “Human CTBP1 (28-378)”. X-ray diffraction, 2 ligands (NAI, CA), 2 pockets (best druggability 0.73). MolNFT v1 #145078 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6CDF
Type: protein
Length: 333 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-terminal-binding protein 1
EC: 1.1.1.-
UniProt: Q13363
Ligands: NAI, CA
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	C-terminal-binding protein 1 (EC 1.1.1.-)	protein	333	36% helix, 16% strand	Q13363

Ligands and binding sites

NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · chains A
CA · Calcium ion · metal · chains A
FMT · Formic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	508	0.73	0.81	62	NAI
2	85	0.39	0.78	18	empty

Compared structures

6CDF · Human CtBP1 (28-378) · the same entry in another collection · chain A against A, TM-score 1.00
Q13363 · AlphaFold monomer V2.0 prediction for C-terminal-binding protein 1 (Q13363) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13363
Elsewhere: RCSB PDB 6CDF · PDBe 6CDF · UniProt Q13363

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