MolNFT v1 · #145005 · protein
Cryo-EM structure of the gasdermin A3 membrane pore
6CB8 · Gasdermin-A3: “Cryo-EM structure of the gasdermin A3 membrane pore”. Electron microscopy, 1 ligand (CDL), 1 pocket (best druggability 0.48). MolNFT v1 #145005 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6CB8
- Type
- protein
- Length
- 230 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gasdermin-A3
- UniProt
- Q5Y4Y6
- Ligands
- CDL
- Pockets
- 1 · best druggability 0.48
Structure
electron microscopy · 1 distinct chain · 17% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gasdermin-A3 | protein | 230 | 17% helix, 35% strand | Q5Y4Y6 |
Ligands and binding sites
- CDL · Cardiolipin · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.48 | 0.75 | 33 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5Y4Y6
- Elsewhere: RCSB PDB 6CB8 · PDBe 6CB8 · UniProt Q5Y4Y6
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