MolNFT v1 · #144998 · protein
Crystal structure of the fak ferm domain
6CB0 · Focal adhesion kinase 1: “Crystal structure of the fak ferm domain”. X-ray diffraction, 8 pockets (best druggability 0.66). MolNFT v1 #144998 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6CB0
- Type
- protein
- Length
- 700 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- UniProt
- Q00944
- Pockets
- 8 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 357 | 40% helix, 22% strand | Q00944 |
| B | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 343 | 40% helix, 23% strand | Q00944 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 481 | 0.66 | 0.77 | 54 | empty |
| 2 | 184 | 0.65 | 0.85 | 33 | empty |
| 3 | 440 | 0.65 | 0.78 | 61 | empty |
| 4 | 180 | 0.50 | 0.77 | 20 | empty |
| 5 | 87 | 0.41 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 668 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00944
- Elsewhere: RCSB PDB 6CB0 · PDBe 6CB0 · UniProt Q00944
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