MolNFT v1 · #144913 · protein

Crystal structure of transient receptor potential (TRP) channel TRPV4 in the presence of gadolinium

6C8H · Transient receptor potential cation channel, subfamily V…: “Crystal structure of transient receptor potential (TRP) channel TRPV4 in the presence of gadolinium”. X-ray diffraction, 1 ligand (GD), 9 pockets (best druggability 0.64).…

PDB: 6C8H
Type: protein
Length: 608 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel, subfamily V, member 4
UniProt: F7BWY7
Ligands: GD
Pockets: 9 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transient receptor potential cation channel, subfamily V, member 4	protein	608	55% helix, 4% strand	F7BWY7

Ligands and binding sites

GD · Gadolinium atom · metal

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.64	0.90	19	empty
2	57	0.62	0.93	17	empty
3	160	0.60	0.82	22	empty
4	292	0.55	0.76	23	empty
5	113	0.47	0.79	19	empty

Compared structures

6C8H · Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F7BWY7
Elsewhere: RCSB PDB 6C8H · PDBe 6C8H · UniProt F7BWY7

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