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Crystal structure of transient receptor potential (TRP) channel TRPV4 in the presence of gadolinium

Analyse Crystal structure of transient receptor potential (TRP) channel TRPV4 in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6C8H
Type: protein
Length: 608 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel, subfamily V, member 4
UniProt: F7BWY7
Ligands: GD
Pockets: 9 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transient receptor potential cation channel, subfamily V, member 4	protein	608	55% helix, 4% strand	F7BWY7

Ligands and binding sites

GD · Gadolinium atom · metal

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.64	0.90	19	empty
2	57	0.62	0.93	17	empty
3	160	0.60	0.82	22	empty
4	292	0.55	0.76	23	empty
5	113	0.47	0.79	19	empty

Compared structures

6C8H · Crystal structure of Transient Receptor Potential (TRP) channel TRPV4 in the presence of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F7BWY7
Elsewhere: RCSB PDB 6C8H · PDBe 6C8H · UniProt F7BWY7

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