MolNFT v1 · #144888 · protein
Crystal structure of D477G ACO/RPE65 chimera, trigonal crystal form
6C7O · Apocarotenoid-15,15'-oxygenase: “Crystal structure of D477G ACO/RPE65 chimera, trigonal crystal form”. X-ray diffraction, 1 ligand (FE2), 5 pockets (best druggability 0.86). MolNFT v1 #144888 on GenesisL1: 3D structure, binding…
- PDB
- 6C7O
- Type
- protein
- Length
- 958 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apocarotenoid-15,15'-oxygenase
- EC
- 1.13.11.75
- UniProt
- P74334
- Ligands
- FE2
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Apocarotenoid-15,15'-oxygenase (EC 1.13.11.75) | protein | 479 | 8% helix, 38% strand | P74334 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1159 | 0.86 | 0.87 | 98 | empty |
| 2 | 1171 | 0.86 | 0.86 | 99 | empty |
| 3 | 417 | 0.77 | 0.86 | 42 | empty |
| 4 | 418 | 0.77 | 0.86 | 42 | empty |
| 5 | 194 | 0.53 | 0.78 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 471 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6C7O · Crystal structure of D477G ACO/RPE65 chimera, trigonal crystal form · the same entry in another collection · chain A against A, TM-score 1.00
- P74334 · AlphaFold monomer V2.0 prediction for apocarotenoid-15,15'-oxygenase (P74334) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P74334
- Elsewhere: RCSB PDB 6C7O · PDBe 6C7O · UniProt P74334
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