MolNFT v1 · #144808 · protein
Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109
6C57: “Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with…”. X-ray diffraction, 1 ligand (FV9). MolNFT v1 #144808 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6C57
- Type
- protein
- Length
- 531 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O95749
- Ligands
- FV9
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 277 | — | O95749 |
| B | — | protein | 254 | — | O95749 |
Ligands and binding sites
- FV9 · {[(2-{3-[(4-fluorobenzene-1-carbonyl) amino]phenyl}thieno[2,3-d]pyrimidin-4-yl) amino]methylene}bis(phosphonic acid) · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6C57 · Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in… · the same entry in another collection · chain A against A, TM-score 1.00
- O95749 · AlphaFold monomer V2.0 prediction for geranylgeranyl pyrophosphate synthase (O95749) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95749
- Elsewhere: RCSB PDB 6C57 · PDBe 6C57 · UniProt O95749
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