UniProt O95749
O95749
O95749 (UniProt O95749): 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O95749
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
Structures
8 records of O95749 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Q80 | Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2Q80 | Crystal structure of human geranylgeranyl pyrophosphate synthase bound to ggpp | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6C56 | Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in its apo form | x-ray diffraction | A, B | VT0 | — |
| 6C57 | Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with… | x-ray diffraction | A, B | FV9 | — |
| 6G31 | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | ZOL, MG | — |
| 6G32 | Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6R4V | Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate | x-ray diffraction | A, C, F, E, B, D | MG, BFQ | — |
| O95749 | AlphaFold monomer V2.0 prediction for geranylgeranyl pyrophosphate synthase (O95749) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 2 records
- BFQ · Ibandronate · in 1 record
- FV9 · {[(2-{3-[(4-fluorobenzene-1-carbonyl) amino]phenyl}thieno[2,3-d]pyrimidin-4-yl) amino]methylene}bis(phosphonic acid) · in 1 record
- VT0 · {[(2-phenylthieno[2,3-d]pyrimidin-4-yl) amino]methylene}bis(phosphonic acid) · in 1 record
- ZOL · Zoledronic acid · in 1 record
Experiment against prediction
- 6R4V chain A against the predicted model O95749: TM-score 1.00, RMSD 0.42 Å
- 6R4V chain C against the predicted model O95749: TM-score 0.99, RMSD 0.62 Å
- 6G31 chain F against the predicted model O95749: TM-score 0.99, RMSD 0.56 Å
- 6G31 chain B against the predicted model O95749: TM-score 0.99, RMSD 0.60 Å
- 6R4V chain F against the predicted model O95749: TM-score 0.99, RMSD 0.67 Å
- 6G31 chain C against the predicted model O95749: TM-score 0.99, RMSD 0.66 Å
- 6R4V chain D against the predicted model O95749: TM-score 0.99, RMSD 0.67 Å
- 6G31 chain J against the predicted model O95749: TM-score 0.99, RMSD 0.64 Å
- 2Q80 chain C against the predicted model O95749: TM-score 0.99, RMSD 0.69 Å
- 2Q80 chain C against the predicted model O95749: TM-score 0.99, RMSD 0.69 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.