MolNFT v1 · #144618 · protein
Complex structure of fak fat domain and dcc P3 motif
6BZ3 · Focal adhesion kinase 1: “Complex structure of fak fat domain and dcc P3 motif”. X-ray diffraction, 1 ligand (CA), 1 pocket (best druggability 0.53). MolNFT v1 #144618 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BZ3
- Type
- protein
- Length
- 287 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1; Netrin receptor dcc
- EC
- 2.7.10.2
- UniProt
- P34152, Q63155
- Ligands
- CA
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 3 distinct chains · 89% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 125 | 89% helix, 0% strand | P34152 |
| B | Netrin receptor dcc | protein | 18 | 89% helix, 0% strand | Q63155 |
| D | Netrin receptor dcc | protein | 19 | 89% helix, 0% strand | Q63155 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 256 | 0.53 | 0.76 | 42 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1958 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 512 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 505 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 347 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 339 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6BZ3 · Complex structure of FAK FAT domain and DCC P3 motif · the same entry in another collection · chain D against D, TM-score 1.00
- P34152 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (P34152) · a predicted model of the same protein · chain C against A, TM-score 0.81
- Q63155 · AlphaFold monomer V2.0 prediction for netrin receptor dcc (Q63155) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34152
- Every structure of UniProt Q63155
- Elsewhere: RCSB PDB 6BZ3 · PDBe 6BZ3 · UniProt P34152 · UniProt Q63155
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.