MolNFT v1 · #144536 · protein
Crystal structure of the TRPV2 ion channel
6BWM · Transient receptor potential cation channel subfamily V…: “Crystal structure of the TRPV2 ion channel”. X-ray diffraction, 1 ligand (CA), 17 pockets (best druggability 0.80). MolNFT v1 #144536 on GenesisL1: 3D structure, binding…
- PDB
- 6BWM
- Type
- protein
- Length
- 1,205 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 2
- UniProt
- G1SNM3
- Ligands
- CA
- Pockets
- 17 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 2 | protein | 606 | 59% helix, 5% strand | G1SNM3 |
| B | Transient receptor potential cation channel subfamily V member 2 | protein | 599 | 58% helix, 6% strand | G1SNM3 |
Ligands and binding sites
- CA · Calcium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.80 | 0.84 | 58 | empty |
| 2 | 846 | 0.79 | 0.82 | 73 | empty |
| 3 | 514 | 0.73 | 0.81 | 63 | empty |
| 4 | 297 | 0.62 | 0.80 | 37 | empty |
| 5 | 266 | 0.62 | 0.80 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1648 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6BWM · Crystal structure of the TRPV2 ion channel · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1SNM3
- Elsewhere: RCSB PDB 6BWM · PDBe 6BWM · UniProt G1SNM3
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