MolNFT v1 · #144310 · protein

Structure of the cold- and menthol-sensing ion channel TRPM8

6BPQ · Transient receptor potential cation channel subfamily M…: “Structure of the cold- and menthol-sensing ion channel TRPM8”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #144310 on GenesisL1: 3D structure…

PDB: 6BPQ
Type: protein
Length: 3,340 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 8
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 67% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily M member 8	protein	835	67% helix, 5% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1126	0.80	0.81	133	empty
2	1114	0.80	0.81	132	empty
3	669	0.80	0.84	102	empty
4	1041	0.79	0.81	80	empty
5	1134	0.79	0.80	94	empty

Interfaces

6 interfaces between chains.

B–C · 2299 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 2296 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 2286 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 2284 Å² buried · 4 hydrogen bonds · protein-protein
B–D · 12 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6BPQ · Structure of the cold- and menthol-sensing ion channel TRPM8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6BPQ · PDBe 6BPQ

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