Research workbench
Structure of the cold- and menthol-sensing ion channel TRPM8
Analyse Structure of the cold- and menthol-sensing ion channel TRPM8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6BPQ
- Type
- protein
- Length
- 3,340 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily M member 8
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 67% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily M member 8 | protein | 835 | 67% helix, 5% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.80 | 0.81 | 133 | empty |
| 2 | 1114 | 0.80 | 0.81 | 132 | empty |
| 3 | 669 | 0.80 | 0.84 | 102 | empty |
| 4 | 1041 | 0.79 | 0.81 | 80 | empty |
| 5 | 1134 | 0.79 | 0.80 | 94 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2299 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 2296 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 2286 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 2284 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 12 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6BPQ · Structure of the cold- and menthol-sensing ion channel TRPM8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6BPQ · PDBe 6BPQ
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