MolNFT v1 · #144247 · protein
Crystal structure of AP2 MU1 adaptin C-terminal domain with irs-1 peptide
6BNT · Ap-2 complex subunit mu: “Crystal structure of AP2 MU1 adaptin C-terminal domain with irs-1 peptide”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #144247 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6BNT
- Type
- protein
- Length
- 257 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit mu; Insulin receptor substrate 1
- UniProt
- Q96CW1, P35568
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 58% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit mu | protein | 250 | 1% helix, 59% strand | Q96CW1 |
| B | Insulin receptor substrate 1 | protein | 7 | 0% helix, 29% strand | P35568 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.43 | 0.76 | 20 | empty |
| 2 | 51 | 0.27 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 407 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6BNT · Crystal structure of AP2 mu1 adaptin C-terminal domain with IRS-1 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q96CW1 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (Q96CW1) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P35568 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 1 (P35568) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96CW1
- Every structure of UniProt P35568
- Elsewhere: RCSB PDB 6BNT · PDBe 6BNT · UniProt Q96CW1 · UniProt P35568
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