MolNFT v1 · #144227 · protein

Crystal structure of DDB1-crbn-BRD4(BD1) complex bound to DBET70 protac

6BN9: “Crystal structure of DDB1-crbn-BRD4(BD1) complex bound to DBET70 protac”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #144227 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6BN9
Type: protein
Length: 1,310 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q16531, Q96SW2, O60885
Ligands: ZN

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	808	—	Q16531
B	—	protein	375	—	Q96SW2
C	—	protein	127	—	O60885

Ligands and binding sites

ZN · Zinc ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6BN9 · Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC · the same entry in another collection · chain A against A, TM-score 1.00
Q96SW2 · AlphaFold monomer V2.0 prediction for protein cereblon (Q96SW2) · a predicted model of the same protein · chain B against A, TM-score 0.99
Q16531 · AlphaFold monomer V2.0 prediction for DNA damage-binding protein 1 (Q16531) · a predicted model of the same protein · chain A against A, TM-score 0.98
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain C against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16531
Every structure of UniProt Q96SW2
Every structure of UniProt O60885
Elsewhere: RCSB PDB 6BN9 · PDBe 6BN9 · UniProt Q16531 · UniProt Q96SW2 · UniProt O60885

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