Salvador hippo sarah domain complex

Structure

x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).

Ligands and binding sites

• NI · Nickel (II) ion · metal · chains B
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 1744 Ų buried · 22 hydrogen bonds · protein-protein

Compared structures

• 6BN1 · Salvador Hippo SARAH domain complex · the same entry in another collection · chain A against A, TM-score 1.00
• Q9VCR6 · AlphaFold monomer V2.0 prediction for scaffold protein salvador (Q9VCR6) · a predicted model of the same protein · chain B against A, TM-score 0.93
• Q8T0S6 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase hippo (Q8T0S6) · a predicted model of the same protein · chain A against A, TM-score 0.79

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8T0S6
• Every structure of UniProt Q9VCR6
• Elsewhere: RCSB PDB 6BN1 · PDBe 6BN1 · UniProt Q8T0S6 · UniProt Q9VCR6