MolNFT v1 · #144075 · protein
The structure of the actin-smooth muscle myosin motor domain complex in the rigor state
6BIH · Myosin-11: “The structure of the actin-smooth muscle myosin motor domain complex in the rigor state”. Electron microscopy, 2 ligands (ADP, MG), 11 pockets (best druggability 0.80). MolNFT v1 #144075 on GenesisL1: 3D structure…
- PDB
- 6BIH
- Type
- protein
- Length
- 1,104 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-11; Actin, alpha skeletal muscle
- UniProt
- P10587, P68135
- Ligands
- ADP, MG
- Pockets
- 11 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Myosin-11 | protein | 729 | 44% helix, 15% strand | P10587 |
| C | Actin, alpha skeletal muscle | protein | 375 | 40% helix, 17% strand | P68135 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 975 | 0.80 | 0.81 | 87 | empty |
| 2 | 469 | 0.76 | 0.85 | 58 | ADP, MG |
| 3 | 1038 | 0.75 | 0.78 | 82 | empty |
| 4 | 323 | 0.67 | 0.82 | 51 | empty |
| 5 | 208 | 0.60 | 0.81 | 34 | empty |
Interfaces
1 interface between chains.
- H–C · 588 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6BIH · The Structure of the Actin-Smooth Muscle Myosin Motor Domain Complex in the Rigor State · the same entry in another collection · chain H against H, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain C against A, TM-score 0.93
- P10587 · AlphaFold monomer V2.0 prediction for myosin-11 (P10587) · a predicted model of the same protein · chain H against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10587
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 6BIH · PDBe 6BIH · UniProt P10587 · UniProt P68135
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