MolNFT v1 · #144036 · protein

Crystal structure of pseduokinase PEAK1 (sugen kinase 269)

6BHC · Pseudopodium-enriched atypical kinase 1: “Crystal structure of pseduokinase PEAK1 (sugen kinase 269)”. X-ray diffraction, 6 pockets (best druggability 0.50). MolNFT v1 #144036 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6BHC
Type: protein
Length: 371 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pseudopodium-enriched atypical kinase 1
EC: 2.7.10.2
UniProt: Q9H792
Pockets: 6 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pseudopodium-enriched atypical kinase 1 (EC 2.7.10.2)	protein	371	49% helix, 14% strand	Q9H792

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	191	0.50	0.77	21	empty
2	180	0.48	0.76	27	empty
3	70	0.44	0.82	18	empty
4	63	0.40	0.80	15	empty
5	61	0.38	0.79	14	empty

Compared structures

6BHC · Crystal structure of pseduokinase PEAK1 (Sugen Kinase 269) · the same entry in another collection · chain A against A, TM-score 1.00
Q9H792 · AlphaFold monomer V2.0 prediction for inactive tyrosine-protein kinase PEAK1 (Q9H792) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H792
Elsewhere: RCSB PDB 6BHC · PDBe 6BHC · UniProt Q9H792

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