MolNFT v1 · #144008 · protein
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in lmng
6BGJ · Anoctamin-1: “Cryo-EM structure of the TMEM16A calcium-activated chloride channel in lmng”. Electron microscopy, 1 ligand (CA), 13 pockets (best druggability 0.85). MolNFT v1 #144008 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6BGJ
- Type
- protein
- Length
- 980 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anoctamin-1
- UniProt
- Q8BHY3
- Ligands
- CA
- Pockets
- 13 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anoctamin-1 | protein | 490 | 66% helix, 0% strand | Q8BHY3 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1119 | 0.85 | 0.85 | 122 | empty |
| 2 | 913 | 0.83 | 0.84 | 107 | empty |
| 3 | 458 | 0.69 | 0.80 | 53 | empty |
| 4 | 558 | 0.64 | 0.75 | 54 | empty |
| 5 | 73 | 0.59 | 0.90 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 622 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BHY3
- Elsewhere: RCSB PDB 6BGJ · PDBe 6BGJ · UniProt Q8BHY3
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