MolNFT v1 · #143962 · protein

Cryo-EM structure of human insulin degrading enzyme in complex with insulin

6BF8 · Insulin-degrading enzyme: “Cryo-EM structure of human insulin degrading enzyme in complex with insulin”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #143962 on GenesisL1: 3D structure, binding sites and…

PDB: 6BF8
Type: protein
Length: 1,888 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin-degrading enzyme
EC: 3.4.24.56
UniProt: P14735
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 2 distinct chains · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin-degrading enzyme (EC 3.4.24.56)	protein	949	41% helix, 16% strand	P14735
B	Insulin-degrading enzyme (EC 3.4.24.56)	protein	939	40% helix, 16% strand	P14735

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1063	0.85	0.85	102	empty
2	1043	0.77	0.79	101	empty
3	1073	0.74	0.77	105	empty
4	173	0.72	0.89	46	empty
5	271	0.72	0.85	47	empty

Interfaces

1 interface between chains.

A–B · 1430 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6BF8 · Cryo-EM structure of human insulin degrading enzyme in complex with insulin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14735
Elsewhere: RCSB PDB 6BF8 · PDBe 6BF8 · UniProt P14735

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