MolNFT v1 · #143895 · protein
Crystal structure of human apo-FRIZZLED4 receptor
6BD4 · Frizzled-4/RUBREDOXIN chimeric protein: “Crystal structure of human apo-FRIZZLED4 receptor”. X-ray diffraction, 4 ligands (OLA, ZN, UNX), 3 pockets (best druggability 0.82). MolNFT v1 #143895 on GenesisL1: 3D structure, binding…
- PDB
- 6BD4
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Frizzled-4/RUBREDOXIN chimeric protein
- UniProt
- Q9ULV1, P00268
- Ligands
- OLA, ZN, UNX, SO4
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Frizzled-4/RUBREDOXIN chimeric protein | protein | 379 | 61% helix, 7% strand | Q9ULV1, P00268 |
Ligands and binding sites
- OLA · Oleic acid · ligand · 5 copies · chains A
- ZN · Zinc ion · metal · chains A
- UNX · Unknown atom or ion · ion · 4 copies · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.82 | 0.89 | 65 | UNX |
| 2 | 52 | 0.38 | 0.81 | 12 | empty |
| 3 | 105 | 0.35 | 0.73 | 18 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6BD4 · Crystal structure of human apo-Frizzled4 receptor · the same entry in another collection · chain A against A, TM-score 1.00
- Q9ULV1 · AlphaFold monomer V2.0 prediction for frizzled-4 (Q9ULV1) · a predicted model of the same protein · chain A against A, TM-score 0.84
- P00268 · AlphaFold monomer V2.0 prediction for rubredoxin (P00268) · a predicted model of the same protein · chain A against A, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULV1
- Every structure of UniProt P00268
- Elsewhere: RCSB PDB 6BD4 · PDBe 6BD4 · UniProt Q9ULV1 · UniProt P00268
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.