MolNFT v1 · #143873 · protein
Crystal structure of REV7-K44A/R124A/A135D in complex with REV3-RBM2 (residues 1988-2014)
6BCD · Mitotic spindle assembly checkpoint protein MAD2B: “Crystal structure of REV7-K44A/R124A/A135D in complex with REV3-RBM2 (residues 1988-2014)”. X-ray diffraction, 2 pockets (best druggability 0.32). MolNFT v1 #143873 on GenesisL1…
- PDB
- 6BCD
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; DNA polymerase zeta catalytic subunit
- EC
- 2.7.7.7
- UniProt
- Q9UI95, O60673
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 205 | 34% helix, 35% strand | Q9UI95 |
| B | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) | protein | 25 | 40% helix, 24% strand | O60673 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.32 | 0.77 | 14 | empty |
| 2 | 78 | 0.31 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1287 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 6BCD · Crystal structure of Rev7-K44A/R124A/A135D in complex with Rev3-RBM2 (residues 1988-2014) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UI95
- Every structure of UniProt O60673
- Elsewhere: RCSB PDB 6BCD · PDBe 6BCD · UniProt Q9UI95 · UniProt O60673
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