MolNFT v1 · #143760 · protein
Crystal structure of the N-terminal domain of human METTL16 in complex with sah
6B92 · U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase: “Crystal structure of the N-terminal domain of human METTL16 in complex with sah”. X-ray diffraction, 1 ligand (SAH), 4 pockets (best druggability 0.57). MolNFT v1 #143760…
- PDB
- 6B92
- Type
- protein
- Length
- 260 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
- EC
- 2.1.1.-, 2.1.1.62
- UniProt
- Q86W50
- Ligands
- SAH
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.-, 2.1.1.62) | protein | 260 | 40% helix, 20% strand | Q86W50 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.57 | 0.80 | 28 | SAH |
| 2 | 129 | 0.41 | 0.74 | 24 | empty |
| 3 | 89 | 0.37 | 0.76 | 19 | empty |
| 4 | 78 | 0.34 | 0.75 | 15 | empty |
Compared structures
- 6B92 · Crystal Structure of the N-terminal domain of human METTL16 in complex with SAH · the same entry in another collection · chain A against A, TM-score 1.00
- Q86W50 · AlphaFold monomer V2.0 prediction for RNA N6-adenosine- methyltransferase METTL16 (Q86W50) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86W50
- Elsewhere: RCSB PDB 6B92 · PDBe 6B92 · UniProt Q86W50
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