MolNFT v1 · #143721 · protein

Cryo-EM structure of human insulin degrading enzyme

6B7Y · Insulin-degrading enzyme: “Cryo-EM structure of human insulin degrading enzyme”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #143721 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6B7Y
Type: protein
Length: 1,888 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin-degrading enzyme
EC: 3.4.24.56
UniProt: P14735
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 2 distinct chains · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin-degrading enzyme (EC 3.4.24.56)	protein	949	42% helix, 16% strand	P14735
B	Insulin-degrading enzyme (EC 3.4.24.56)	protein	939	43% helix, 16% strand	P14735

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1174	0.86	0.87	102	empty
2	198	0.82	0.95	45	empty
3	217	0.81	0.93	50	empty
4	169	0.80	0.95	42	empty
5	107	0.79	0.98	33	empty

Interfaces

1 interface between chains.

A–B · 1390 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

6B7Y · Cryo-EM structure of human insulin degrading enzyme · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14735
Elsewhere: RCSB PDB 6B7Y · PDBe 6B7Y · UniProt P14735

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