MolNFT v1 · #143630 · protein
Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome
6B5B · Baculoviral iap repeat-containing protein 1E: “Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #143630 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6B5B
- Type
- protein
- Length
- 3,073 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Baculoviral iap repeat-containing protein 1E; Nlr family card domain-containing protein…
- UniProt
- Q9R016, Q3UP24, G8UUW9
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 41% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Baculoviral iap repeat-containing protein 1E | protein | 1199 | 39% helix, 10% strand | Q9R016 |
| B, C | Nlr family card domain-containing protein 4 | protein | 903 | 40% helix, 13% strand | Q3UP24 |
| F | Flagellin | protein | 68 | 78% helix, 0% strand | G8UUW9 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.85 | 0.90 | 90 | empty |
| 2 | 294 | 0.85 | 0.95 | 46 | empty |
| 3 | 916 | 0.84 | 0.85 | 120 | empty |
| 4 | 1152 | 0.84 | 0.85 | 137 | empty |
| 5 | 1067 | 0.81 | 0.82 | 103 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1729 Ų buried · 13 hydrogen bonds · protein-protein
- A–F · 1531 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1521 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6B5B · Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome · the same entry in another collection · chain A against A, TM-score 1.00
- Q9R016 · AlphaFold monomer V2.0 prediction for baculoviral iap repeat- containing protein 1E… · a predicted model of the same protein · chain A against A, TM-score 0.85
- Q3UP24 · AlphaFold monomer V2.0 prediction for nlr family card domain- containing protein 4… · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9R016
- Every structure of UniProt Q3UP24
- Every structure of UniProt G8UUW9
- Elsewhere: RCSB PDB 6B5B · PDBe 6B5B · UniProt Q9R016 · UniProt Q3UP24 · UniProt G8UUW9
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