MolNFT v1 · #143585 · protein
Crystal structure of cstf-50 in complex with cstf-77
6B3X · Cleavage stimulation factor subunit 1: “Crystal structure of cstf-50 in complex with cstf-77”. X-ray diffraction, 1 pocket (best druggability 0.82). MolNFT v1 #143585 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6B3X
- Type
- protein
- Length
- 341 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cleavage stimulation factor subunit 1; Cleavage stimulation factor subunit 3
- UniProt
- Q05048, Q12996
- Pockets
- 1 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cleavage stimulation factor subunit 1 | protein | 327 | 3% helix, 46% strand | Q05048 |
| B | Cleavage stimulation factor subunit 3 | protein | 14 | 21% helix, 14% strand | Q12996 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 723 | 0.82 | 0.86 | 59 | empty |
Interfaces
1 interface between chains.
- A–B · 855 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6B3X · Crystal structure of CstF-50 in complex with CstF-77 · the same entry in another collection · chain A against A, TM-score 1.00
- Q05048 · AlphaFold monomer V2.0 prediction for cleavage stimulation factor subunit 1 (Q05048) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q12996 · AlphaFold monomer V2.0 prediction for cleavage stimulation factor subunit 3 (Q12996) · a predicted model of the same protein · chain B against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05048
- Every structure of UniProt Q12996
- Elsewhere: RCSB PDB 6B3X · PDBe 6B3X · UniProt Q05048 · UniProt Q12996
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