MolNFT v1 · #143510 · protein + DNA
Hydrogen bonding complementary, not size complementarity is key in the formation of the double helix
6B1S · Reverse transcriptase: “Hydrogen bonding complementary, not size complementarity is key in the formation of the double helix”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #143510 on GenesisL1: 3D structure…
- PDB
- 6B1S
- Type
- protein + DNA
- Length
- 523 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reverse transcriptase; DNA (5'-D(*CP*TP*TP*AP*TP*AP*(CGY)P*(CGY)…
- EC
- 2.7.7.49
- UniProt
- P03355
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reverse transcriptase (EC 2.7.7.49) | protein | 245 | 30% helix, 24% strand | P03355 |
| B | Reverse transcriptase (EC 2.7.7.49) | protein | 246 | 32% helix, 22% strand | P03355 |
| E, F | DNA (5'-D(*CP*TP*TP*AP*TP*AP*(CGY)P*(CGY) P*TP*TP*TP*AP*TP*AP*AP*G)-3') | dna | 16 | — | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.52 | 0.77 | 30 | empty |
| 2 | 255 | 0.52 | 0.75 | 37 | empty |
Interfaces
5 interfaces between chains.
- E–F · 692 Ų buried · 64 hydrogen bonds · nucleic-nucleic
- A–E · 236 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–F · 233 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–E · 208 Ų buried · 4 hydrogen bonds · protein-nucleic
- A–F · 204 Ų buried · 4 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified (nucleotide modification).
Compared structures
- 6B1S · Hydrogen Bonding Complementary, not size complementarity is key in the formation of the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Elsewhere: RCSB PDB 6B1S · PDBe 6B1S · UniProt P03355
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