Research workbench
Hydrogen bonding complementary, not size complementarity is key in the formation of the double helix
Analyse Hydrogen bonding complementary, not size complementarity is key in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B1S
- Type
- protein + DNA
- Length
- 523 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reverse transcriptase; DNA (5'-D(*CP*TP*TP*AP*TP*AP*(CGY)P*(CGY)…
- EC
- 2.7.7.49
- UniProt
- P03355
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reverse transcriptase (EC 2.7.7.49) | protein | 245 | 30% helix, 24% strand | P03355 |
| B | Reverse transcriptase (EC 2.7.7.49) | protein | 246 | 32% helix, 22% strand | P03355 |
| E, F | DNA (5'-D(*CP*TP*TP*AP*TP*AP*(CGY)P*(CGY) P*TP*TP*TP*AP*TP*AP*AP*G)-3') | dna | 16 | — | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.52 | 0.77 | 30 | empty |
| 2 | 255 | 0.52 | 0.75 | 37 | empty |
Interfaces
5 interfaces between chains.
- E–F · 692 Ų buried · 64 hydrogen bonds · nucleic-nucleic
- A–E · 236 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–F · 233 Ų buried · 4 hydrogen bonds · protein-nucleic
- B–E · 208 Ų buried · 4 hydrogen bonds · protein-nucleic
- A–F · 204 Ų buried · 4 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified (nucleotide modification).
Compared structures
- 6B1S · Hydrogen Bonding Complementary, not size complementarity is key in the formation of the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Elsewhere: RCSB PDB 6B1S · PDBe 6B1S · UniProt P03355
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.