MolNFT v1 · #143464 · protein
Estrogen receptor alpha ligand binding domain in complex with LSZ102
6B0F: “Estrogen receptor alpha ligand binding domain in complex with LSZ102”. X-ray diffraction, 1 ligand (C6V), 6 pockets (best druggability 0.78). MolNFT v1 #143464 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6B0F
- Type
- protein
- Length
- 389 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Estrogen receptor
- UniProt
- P03372
- Ligands
- C6V
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Estrogen receptor | protein | 204 | 72% helix, 3% strand | P03372 |
| B | Estrogen receptor | protein | 185 | 74% helix, 4% strand | P03372 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.78 | 0.90 | 30 | C6V |
| 2 | 238 | 0.77 | 0.89 | 22 | C6V |
| 3 | 123 | 0.63 | 0.87 | 20 | empty |
| 4 | 97 | 0.60 | 0.87 | 16 | GOL |
| 5 | 303 | 0.59 | 0.78 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1346 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Elsewhere: RCSB PDB 6B0F · PDBe 6B0F · UniProt P03372
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