MolNFT v1 · #143463 · protein
Crystal structure of PFS25 in complex with the transmission blocking antibody 1260
6B0E · 1260 antibody, light chain: “Crystal structure of PFS25 in complex with the transmission blocking antibody 1260”. X-ray diffraction, 6 pockets (best druggability 0.79). MolNFT v1 #143463 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6B0E
- Type
- protein
- Length
- 590 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1260 antibody, light chain; 1260 antibody, heavy chain; 25 kda ookinete surface antigen
- UniProt
- P13829
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1260 antibody, light chain | protein | 217 | 6% helix, 50% strand | — |
| B | 1260 antibody, heavy chain | protein | 216 | 4% helix, 47% strand | — |
| E | 25 kda ookinete surface antigen | protein | 157 | 4% helix, 44% strand | P13829 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.79 | 0.80 | 104 | empty |
| 2 | 75 | 0.64 | 0.92 | 28 | empty |
| 3 | 288 | 0.55 | 0.76 | 31 | empty |
| 4 | 364 | 0.54 | 0.74 | 45 | empty |
| 5 | 114 | 0.36 | 0.73 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1752 Ų buried · 15 hydrogen bonds · protein-protein
- B–E · 758 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 252 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 6B0E · Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260 · the same entry in another collection · chain B against B, TM-score 1.00
- P13829 · AlphaFold monomer V2.0 prediction for 25 kda ookinete surface antigen (P13829) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13829
- Elsewhere: RCSB PDB 6B0E · PDBe 6B0E · UniProt P13829
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