Research workbench
Crystal structure of PFS25 in complex with the transmission blocking antibody 1260
Analyse Crystal structure of PFS25 in complex with the transmission blocking antibody… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6B0E
- Type
- protein
- Length
- 590 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1260 antibody, light chain; 1260 antibody, heavy chain; 25 kda ookinete surface antigen
- UniProt
- P13829
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1260 antibody, light chain | protein | 217 | 6% helix, 50% strand | — |
| B | 1260 antibody, heavy chain | protein | 216 | 4% helix, 47% strand | — |
| E | 25 kda ookinete surface antigen | protein | 157 | 4% helix, 44% strand | P13829 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.79 | 0.80 | 104 | empty |
| 2 | 75 | 0.64 | 0.92 | 28 | empty |
| 3 | 288 | 0.55 | 0.76 | 31 | empty |
| 4 | 364 | 0.54 | 0.74 | 45 | empty |
| 5 | 114 | 0.36 | 0.73 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1752 Ų buried · 15 hydrogen bonds · protein-protein
- B–E · 758 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 252 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 6B0E · Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260 · the same entry in another collection · chain B against B, TM-score 1.00
- P13829 · AlphaFold monomer V2.0 prediction for 25 kda ookinete surface antigen (P13829) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13829
- Elsewhere: RCSB PDB 6B0E · PDBe 6B0E · UniProt P13829
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